Figure 10. MYC overexpression sensitizes human ovarian epithelial cells to the anti-proliferative action of doxycycline, alone or in combination with CX-5461.

(A) Doxycycline inhibits cell proliferation (assessed both by MTT assay, shown on the left, and EdU incorporation assay, shown on the right) significantly more in IOSE-MYC2 than in IOSE-Ctrl. (B) MTT assay showing that doxycycline (15 μM) significantly enhances the antiproliferative effect of CX-5461 (5-25 nM) in IOSE-MYC2 cells. ^*p<0.05, ^**p<0.01, ^***p<0.001.