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. 2017 Dec 22;9(4):5016–5031. doi: 10.18632/oncotarget.23579

Figure 8. MYC-induced upregulation of mitochondrial rRNA transcription and ribogenesis contributes to promote proliferation of human ovarian epithelial cells.

Figure 8

(A) qRT-PCR showing MYC dose-dependent upregulation of genes involved in mitochondrial rRNA transcription and ribogenesis (left) as well as 12-16S mt-rRNA (right) in IOSE-MYC and IOSE-MYC2 cells relative to IOSE-Ctrl. (B) Transient MYC knock down by siRNA significantly reduces both POLRMT and mt-rRNA transcription (assessed by 12-16S mt-rRNA qRT-PCR) in IOSE-MYC2. (C) Transient POLRMT knock down in IOSE-MYC2 cells, by reducing mt-rRNA transcription (left), leads to decreased proliferation (assessed by EdU incorporation) (middle and right). *p<0.05, **p<0.01, ***p<0.001.