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. 2017 Dec 26;9(4):5137–5154. doi: 10.18632/oncotarget.23702

Figure 7. H&E and IHC staining of metastatic lung nodules in the nude mice model.

Figure 7

(A) Representative images (40X, 100X and 400X) of H&E stained lung sections from nude mice injected via the tail vein with BGC-823-FAT4-KO and BGC-823-KO-NC cells. (B) Representative images show IHC staining with anti-FAT4 antibody of lung sections from BGC-823-FAT4-KO and BGC-823-KO-NC group mice. FAT4 is positive staining in the lung metastatic tumor nodules of BGC-823-KO-NC group, whereas it negative expresses in BGC-823-FAT4-KO group. Scale bar, 100 μm. (C) Histogram shows Ki-67 expression and index (%) in lungs of the BGC-823-FAT4-KO and BGC-823-KO-NC group mice. As shown, the BGC-823-FAT4-KO group shows higher Ki-67 index (%) than BGC-823-KO-NC group. Data represent mean ± SD from 3 independent experiments. Scale bar, 100 μm. * denotes P < 0.05 compared to control.