Table 3. Association between FAT4 methylation status and clinicopathological factors.
| Clinical parameters | FAT4 | t/χ2 | P | |
|---|---|---|---|---|
| Unmethylation | Methylation | |||
| Age(yrs) | 61.00±13.14 | 62.50±14.90 | ||
| Gender | 0.116 | 0.733 | ||
| Male | 91(69.5%) | 40(30.5%) | ||
| Female | 28(66.7%) | 14(33.3%) | ||
| Location | 4.390 | 0.111 | ||
| Proximal | 12(52.2%) | 11(47.8%) | ||
| Middle | 45(67.2%) | 22(32.8%) | ||
| Distal | 62(74.7%) | 21(25.3%) | ||
| Size | 1.117 | 0.291 | ||
| <5cm | 61(72.6%) | 23(27.4%) | ||
| ≥5cm | 58(65.2%) | 31(34.8%) | ||
| Histology type | 6.962 | 0.073 | ||
| Papillary adenocarcinoma | 1(20.0%) | 4(80.0%) | ||
| Tubular adenocarcinoma | 96(72.2%) | 37(27.8%) | ||
| Mucinous adenocarcinoma | 4(57.1%) | 3(42.9%) | ||
| Signet-ring cell carcinoma | 18(64.3%) | 10(35.7%) | ||
| Lauren classification | 13.917 | 0.000 | ||
| Diffuse type | 55(85.9%) | 9(14.1%) | ||
| Intestinal type | 64(58.7%) | 45(41.3%) | ||
| Differentiation | 2.413 | 0.299 | ||
| Well | 0(0.00%) | 1(100.0%) | ||
| Moderately | 32(66.7%) | 16(33.3%) | ||
| Poorly | 87(70.2%) | 37(29.8%) | ||
| Invasion Depth (T Grade) | 11.119 | 0.011 | ||
| T1 | 15(93.8%) | 1(6.3%) | ||
| T2 | 29(74.4%) | 10(25.6%) | ||
| T3 | 64(68.1%) | 30(31.9%) | ||
| T4 | 11(45.8%) | 13(54.2%) | ||
| Lymphatic Metastasis (N Grade) | 20.846 | 0.000 | ||
| N0 | 43(86.0%) | 7(14.0%) | ||
| N1 | 26(78.8%) | 7(21.2%) | ||
| N2 | 26(68.4%) | 12(31.6%) | ||
| N3 | 24(46.2%) | 28(53.8%) | ||
| Distant metastasis (M Grade) | 29.093 | 0.000 | ||
| M0 | 94(82.5%) | 20(17.5%) | ||
| M1 | 25(42.4%) | 34(57.6%) | ||
| TNM Stages | 32.214 | 0.000 | ||
| I | 26(92.9%) | 2(7.1%) | ||
| II | 51(85.0%) | 9(15.0%) | ||
| III | 17(65.4%) | 9(34.6%) | ||
| IV | 25(42.4%) | 34(57.6%) | ||
| Lymphatic metastasis | 9.706 | 0.002 | ||
| No | 43(86.0%) | 7(14.0%) | ||
| Yes | 76(61.8%) | 47(38.2%) | ||
| Vascular invasion | 11.978 | 0.001 | ||
| No | 92(76.7%) | 28(23.3%) | ||
| Yes | 26(50.0%) | 26(50.0%) | ||
| FAT4 expression (IHC Result) | 69.677 | 0.000 | ||
| Negative | 29(36.7%) | 50(63.3%) | ||
| Positive | 90(95.7%) | 4(4.3%) | ||
All cases were classified according to the World Health Organization's (2010) pathological classification of gastric cancer. Invasion Depth (T Grade) grade T1 includes T1a and T1b, T4 includes T4a and T4b. Lymphatic Metastasis (N Grade) grade N3 includes N3a and N3b. TNM grade I includes Ia and Ib, TNM grade II includes IIa and IIb, TNM grade III includes IIIa, IIIb and IIIc.