Table 1. PKG1α, PKG1β and PKG2 activation constants by PA1, PA2, PA3, PA4, PA5 and PA6.

	FLAG-hPKG1α (n ≥ 3)
	cGMP	PA1	PA2	PA3	PA4	PA5	PA6
mean ± SD	49 ± 4 nM	26 ± 5 nM	4.6 ± 0.2 nM	5.7 ± 1.0 nM	< 0.8 nM	7.7 ± 1.3 nM	< 2 nM
	FLAG-hPKG1β (n ≥ 3)
	cGMP	PA1	PA2	PA3	PA4	PA5	PA6
mean ± SD	430 ± 30 nM	320 ± 20 nM	16 ± 3 nM	13 ± 4 nM	< 1 nM	21 ± 2 nM	< 1 nM
	FSS-hPKG2 (n ≥ 3)
	cGMP	PA1	PA2	PA3	PA4	PA5	PA6
mean ± SD	250 ± 20 nM	28 ± 3 nM	300 ± 45 nM	58 ± 5 nM	< 1 nM	2.1 ± 0.6 nM	110 ± 30 nM