Table 2. The antagonists of β-catenin or other proteins in Wnt pathway and their possible mechanisms.

Name	Possible mechanisms
PKF115-584183	Antagonist of the TCF/β-catenin complex Decreases both cytoplasmic and nuclear β-catenin expression
BC205947	Anthraquinone oxime analog Disrupts the binding of β-catenin to transducin β-like 1; Promotes β-catenin degradation
LF3180	Inhibits the β-catenin/TCF4 interaction Suppresses cell motility, cell-cycle progression, and the overexpression of Wnt target genes; Blocks the self-renewal capacity of cancer stem cells
ICG-001181	Inhibits β-catenin/CREBBP interaction Downregulates Wnt target genes
Salinomycin185	Small molecule inhibitor of LRP6 Downregulates Wnt target genes and cause cancer cell death
Calphostin C182	Antagonist of the TCF/β-catenin complex Degrades β-catenin via a proteasome-dependent
Xanthothricin182	Antagonist of the TCF/β-catenin complex Degrades β-catenin via a proteasome-dependent
FH535184	Suppresses β-catenin /TCF-mediated transcription