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. 2018 Feb 2;8:2274. doi: 10.1038/s41598-018-20715-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Penetrability of FITC-labelled peptide in A549 three-dimensional cellular spheres (3D-MCS). (A) Representative images of A549 MCS treated with 8 μM FITC-labelled HPRP-A1 with or without 64 μM iRGD for 30 min. (B) Changes of the fluorescence intensity of the 23^rd layer of MCS, from center to the margin. (C) Image of the 23^rd layer of MCS treated with HPRP-A1 alone (top) or treated with HPRP-A1 with iRGD (bottom). Green fluorescence indicates FITC-labeled HPRP-A1, the red arrows indicated the fluorescence change distance showed in Fig. 7B.