Table 4.
Univariate and multivariate Cox regression analysis.
| Univariate Analysis | Multivariate Analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| PFS | OS | PFS | OS | |||||
| HR (95, 0%CI) | Sig. | HR (95, 0%CI) | Sig. | HR (95, 0%CI) | Sig. | HR (95, 0%CI) | Sig. | |
| LDH (High vs Normal) | 2,0 (1,1–3,6) | 0,028 | 0,5 (0,–0,9) | 0,016 | — | — | 4,7 (1,7–13,0) | 0,003 |
| Hct (Low vs Normal) | 2,1 (1,1–4,1) | 0,024 | 2,0 (1,0–3,8) | 0,043 | — | — | — | — |
| Group (Resistant vs Sensitive) | 3,2 (1,7–6,2) | <0,001 | 2,5 (1,4–4,6) | 0,003 | 3,0 (2,0–6,0) | 0,001 | 2,0 (1,0–5,0) | 0,001 |
| CTCs (CS) at baseline (≥5 vs <5 CTCs) | 3,4 (1,8–6,6) | <0,001 | 2,9 (1,5–5,4) | 0,001 | 4,9 (2,3–10,6) | <0, 001 | — | — |
| CTCs (CS) post-1st cycle (≥5 vs <5 CTCs) | 1,3 (0,6–3,2) | 0,486 | 2,7 (1,1–6,7) | 0,034 | — | — | — | — |
| CTCs (CS) on PD (≥5 vs <5 CTCs) | — | — | 2,3 (1,2–4,3) | 0,011 | — | — | 2,0 (1,0–6,0) | 0,005 |
| CK+/Ki67+ vs CK+/Ki67− CTCs (baseline) | 1,1 (0,6–2,0) | 0,722 | 0,8 (0,5–1,5) | 0,51 | — | — | — | — |
| CK+/Ki67+ vs CK+/Ki67− CTCs (post 1st cycle) | 1,0 (0,5–2,3) | 0,949 | 1,3 (0,6–2,9) | 0,538 | — | — | — | — |
| CK+/Ki67+ vs CK+/Ki67− (PD) | — | — | 1,1 (0,5–2,3) | 0,909 | — | — | — | — |
| CK+/M30+ vs CK+/M30− (baseline) | 1,2 (0,5–2,8) | 0,735 | 1,6 (0,6–3,7) | 0,326 | — | — | — | — |
| CK+/M30+ vs CK+/M30− (post 1st cycle) | 1,5 (0,8–3,1) | 0,283 | 1,3 (0,6–2,6) | 0,537 | — | — | — | — |
| CK+/M30+ vs CK+/M30− (PD) | — | — | 1,9 (0,6–5,4) | 0,249 | — | — | — | — |
| CK+/Vim+ vs CK+/Vim− (baseline) | 1,6 (0,8–3,2) | 0,200 | 1,6 (0,8–3,2) | 0,224 | — | — | — | — |
| CK+/Vim+ vs CK+/Vim− (post 1st cycle) | 1,9 (0,8–4,1) | 0,126 | 4,9 (2,1–11,8) | <0,001 | — | — | 7,9 (2,9–21,8) | <0,001 |
| CK+/Vim+ vs CK+/Vim− (PD) | — | — | 1,3 (0,7–2,5) | 0,455 | — | — | — | — |