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. 2018 Feb 2;8:2268. doi: 10.1038/s41598-018-20765-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A putative mechanism of S18-2-dependent EMT induction. Our data show that overexpression of S18-2 in PC3 cells enriches the CXCL12-CXCR4 axis. This in turn results in upregulation of the expression of TWIST2, which is the repressor of E-cadherin, thus, EMT is enhanced. Therefore, the more cells express S18-2 protein, the better they gain the ability of migration as shown in zebrafish embryos. [*] indicates induction of gene.