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. 2018 Feb 2;8:2268. doi: 10.1038/s41598-018-20765-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tumorigenicity of the cells, overexpressing S18-2 in comparison with the control cells. PC3, PC3-S18-2-CL03 and PC3S18-2-CL04 cells were injected (2 × 10⁶) subcutaneously into SCID mice. (A) PC3-S18-2-CL03 and PC3-S18-2-CL04 gave smaller tumors compared to the control cells. (B) HE staining of tumors sections showed the formation of the dense tumors by PC3 cells (the top row). S18-2 overexpressing cells produced heterogeneous tumors, infiltrated by lymphocytes (the middle and the bottom rows). Many adipocytes were seen (black arrows). These cells produced multiple foci (green arrows). Also, the multinucleated cells were detected (red arrows).