Figure 10.
Schematic overview of the experimental design. (A) Human immortalized microglial cells were pretreated for 45 min with 50 nM SCH58261 (A2AR antagonist) and then challenged with Zymosan A (50 µg/mL) and PMA (100 nM) for 6 h. (B) Human immortalized microglial cells were challenged with 5 μg/μL ARPE-19 cell debris for 6 h, previously untreated or treated with 50 nM SCH58261. (C) ARPE-19 cell line was cultured with MCM for 48 h. (D) 661 W photoreceptor cell line was cultured with MCM for 48 h.