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. 2018 Feb 2;8:2272. doi: 10.1038/s41598-018-20733-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A_2AR blockade prevents microglia complement cascade alterations induced by ARPE-19 debris. Human microglia were exposed to 5 µg/mL ARPE-19 apoptotic cell debris for 6 h in the presence or absence of A_2AR antagonist. The mRNA expression levels of complement cascade components C3 (A), CFB (B), CFH (C), CFI (D), C5AR1 (E), CD46 (F) and CD55 (G) were assessed by qPCR. Results are normalized to control and presented as the mean ± SEM of 5 independent experiments (the individual data points for each condition are also presented). Kruskall-Wallis test, followed by Dunn’s multiple comparison test.