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. 2018 Feb 2;8:2280. doi: 10.1038/s41598-018-20772-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of compound 312. (a) Compound 312 elicited dose dependent inhibition of RNP activities of various influenza subtypes. (b) Compound 312 showed inhibition of influenza A/PR/8/34. (c) Viral growth curve with compound 312. Compound 312 could impede influenza A/WSN/33 propagation. (d) MDCK cells were infected with 0.01 MOI A/WSN/33 and incubated with 100 μM compound 312 at various time points. Compound 312 was able to attenuate virus when added post infection. (e) SPR study of compound 312 with PAC. Using the ‘1:1 Langmuir binding’ model by BIAevaluation v. 4.1 software, Kd value was estimated to be 37.7 ± 4.6 μM. Data shown represent the mean ± SD of three independent experiments. *Represents p < 0.05, **Represents p < 0.01. (f) MST study of compound 312 with PAC. Kd value was estimated to be 38.2 ± 5.5 μM by MO.Control software using Kd model.