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. 2018 Feb 2;8:2213. doi: 10.1038/s41598-018-19825-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of human glioblastoma tumor growth by tail vein–injected tk-VLPs combined with GCV treatment in a subcutaneous xenograft model. Tail vein-injected tk-VLPs, intraperitoneally injected GCV, or combined tk-VLPs/GCV were administered to nude mice bearing subcutaneous U87 human glioblastoma tumors. (a) Gross pictures of tumor nodules harvested on day 21 from each treatment group. Scale bar = 50 mm. (b) Quantification of tumor nodule weights presented as means ± SD. Combined tk-VLPs/GCV treatment exhibited a significant reduction in the weights of tumor nodules compared to tk-VLP only or GCV only treatment. n = 4, Mann-Whitney U Test, *p < 0.05.