Figure 6.

Splicing regulatory network. Graphical representation of splicing regulation of a functional interaction network of proteins involved in DDR. Circles (nodes) correspond to genes with ASEs that respond to oxaliplatin and that are regulated by hnRNP A1/A2, Sam68 and SRSF10. Lines (edges) indicate interactions and their thickness indicates confidence in data that support the interaction based on the STRING database⁴⁹. Only components with connections are shown (18 of 34 of the oxaliplatin-sensitive ASEs regulated by the three RBPs). Target transcripts are organized vertically in groups that function in apoptosis, DNA repair and cell-cycle control; and horizontally, by individual or combinations of RBPs controlling their splicing.