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. 2018 Feb 2;9:477. doi: 10.1038/s41467-017-02794-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Prophylactic treatment with DHCA/Mal-gluc attenuates variable stress-mediated depression and anxiety phenotypes in both male and female mice. a Schematic design of the experiment. b–e Behavioral responses of male mice following 21 days of CVS. b Splash test (one-way ANOVA, F_3,38 = 4.61, P = 0.008). c NSF test (one-way ANOVA, F_3,39 = 3.23, P = 0.034). d FST (one-way ANOVA, F_3,39 = 10.30, P < 0.0001) and e sucrose preference test (one-way ANOVA, F_3,37 = 1.65, P = 0.197). f–i Behavioral responses of female mice following 6 days of SCVS. f Splash test (one-way ANOVA, F_3,39 = 5.33, P = 0.004). g NSF test (one-way ANOVA, F_3,39 = 5.22, P = 0.004); h FST (one-way ANOVA, F_3,39 = 0.581, P = 0.631) and i sucrose preference test (one-way ANOVA, F_3,37 = 3.312, P = 0.032). All graphs represent mean ± s.e.m., *P < 0.05, **P < 0.01, ***P < 0.001