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. 2018 Feb 2;8:2239. doi: 10.1038/s41598-018-20722-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LH-dependent association of LHR with Gαq is rearranged in the presence of FSHR. Schematic representation and BRET analysis of LH-dependent association of Gαq-Venus with either LHR-Rluc8 (a) or FSHR-Rluc8 (b), expressed in HEK 293 cells stably expressing FSHR or LHR, respectively or in HEK 293 cells. L, LHR-Rluc8 transiently expressed in HEK 293 cells; F, FSHR-Rluc8 transiently expressed in HEK 293 cells; LF, either LHR-Rluc8 or FSHR-Rluc8 in cells stably expressing FSHR or LHR, respectively. Basal BRET was obtained for 1 min prior to LH (100 nm) addition for 1 min and treatments carried out in triplicate. Data is represented as mean ± SEM from n = 3. *p < 0.05, **p < 0.01.