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. 2018 Feb 2;8:2277. doi: 10.1038/s41598-018-20768-5

Figure 7.

Figure 7

Effect of NTS on body weight and adipogenesis in mice fed with a high-fat diet. C57BL/6 mice were fed with a high-fat diet or normal diet for 5 weeks. Each group was divided into two groups, one group was injected with PBS, and the other group was injected with NTS. (A) The photograph was taken 5 weeks after NTS or PBS treatment. From the left, normal diet/ PBS, normal diet/NTS, high-fat diet/PBS, and high-fat diet/NTS. (B) Effect of NTS on weight gain. From day 21, high-fat diet-fed mice injected with NTS had significantly lower body weights compared with PBS-injected mice. Significant difference: ***p < 0.001 compared with the control group. N = 10. (C) Effect of NTS on adipose tissue weight. eWAT and ingWAT were isolated from all groups. The high-fat diet-fed mice injected with NTS had significantly lower mean adipose tissue weight in comparison to the mice injected with PBS. Significant difference: ***p < 0.001, **p < 0.01 compared with the control group. N = 10 (D) H & E staining of adipose tissue. Representative pictures from the groups are shown. Scale bar = 100 μm. (E) Adipocyte size of high-fat diet-fed mice is reduced by NTS treatment. High-fat diet-fed mice injected with NTS had a significant reduction in average cell size compared with the high-fat diet-fed mice injected with PBS. Significant difference: ***p < 0.001, **p < 0.01 compared with the control group. N = 10.