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Schematic diagram depicting OBG’s suppressive effect on expression of ENaCs in kidney. OBG, a aglycone of OUA, functions as a LXRβ agonist to down-regulate ENaC in kidney both in vitro and in vivo where as OUA shows cardiotonic action and cytotoxicity. Notably, OBG doesn’t cause hepatic steatosis which is severe side effect induced by conventional LXR ligands. Thus, OBG is a novel class of LXR ligand as a promising antihypertensive diuretic.
