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. 2018 Feb 2;8:2304. doi: 10.1038/s41598-018-20607-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Progressive ratio deficits in 10-month-old Htt^+/+ and Htt^Q111/+ mice. No genotype effect is observed in (a) the final days to criterion (t_(14.3) = 0.5, p = 0.6), or (b) active/inactive well ratio (t_(15.8) = 0.3, p = 0.8) during the PR task. However, Htt^Q111/+ mice do have (c) reduced total nose pokes (t_(7.8) = 3.0, p = 0.02), reduced rewards/session (t_(12.1) = 3.0, p = 0.01) and a consequently (d) reduced final breakpoint (t_(13.9) = 4.0, p = 0.002) during the PR task. *Indicates p < 0.05. Horizontal lines in the boxes indicate 25th, 50th and 75th percentiles, while vertical lines indicate 1.5 times the interquartile range; outliers beyond these values are graphed as points.