Table 2.

Univariate and multivariate analysis of survival with clinical factors including gremlin1

Clinical factors	Univariate	Multivariate	Hazard ratio	95% confidence interval
Age	0.554	0.799	–
Gender	0.953	0.594	–
Histology	< 0.01	< 0.05	1.993	1.110–3.580
pT	< 0.01	< 0.05	4.584	1.315–15.977
Tumor size	< 0.01	0.28	–
pN	< 0.01	< 0.01	3.68	1.370–9.885
Lymphatic invasion	< 0.01	0.395	–
Venous invasion	< 0.01	0.136	–
Gremlin1	< 0.01	0.076	–

pT tumor depth of invasion, pN nodal involvement