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. 2017 Dec 29;32(1):120–131. doi: 10.1007/s00540-017-2441-0

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Protective effects of coenzyme Q10 (CoQ10) against propofol cytotoxicity in human induced pluripotent stem cell (iPSC)-derived cardiomyocytes. iPSC-derived cardiomyocytes were co-treated with CoQ10 and 50 µg/ml propofol for 48 h. Supplementation of 5 µM CoQ10 protected cardiomyocytes from propofol-induced reduction of cell viability (a), elevation of lactate concentrations in culture media (b), and reduction in cellular ATP levels (c). Data are presented as triangular dots; n = 4 in each experimental condition. *P < 0.05, compared with control conditions (0 µg/ml propofol in triglyceride emulsion). RFU relative fluorescence units, RLU relative luminescence units