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. 2017 Dec 29;32(1):120–131. doi: 10.1007/s00540-017-2441-0

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Effect of coenzyme Q10 (CoQ10) on propofol-induced downregulation of genes regulating mitochondrial energy metabolism. Co-treatment with CoQ10 (5 µM) protected cardiomyocytes from propofol-induced (50 µg/ml for 48 h) reduction in gene expression of PGC-1alpha, NRF1, NDUFS8, SDHB, PPARalpha, and CPT1B. Transcript levels were normalized to ACTB. Data are presented as triangular dots; n = 4–5 in each experimental condition. *P < 0.05, compared with control conditions (0 µg/ml propofol in triglyceride emulsion)