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. 2017 Dec 27;97(3):387–400. doi: 10.1007/s00277-017-3191-7

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Rates of grade 3 and 4 neutropenia in commonly used regimens for the treatment of multiple myeloma. Each bubble represents one study. The size of the bubbles represents the number of patients in the study. Bubbles outlined in red are observational studies; the remainder are phase 3 clinical trials. Two points for lenalidomide + dexamethasone are not visible: an observational study with a neutropenia incidence of 16% (N = 50) and an observational study with a neutropenia incidence of 35% (N = 31)