Table 1.
Neutropenia rates by regimen
| Regimen | Range of reported grade 3 and 4 neutropenia, % | Number of studies |
|---|---|---|
| Thalidomide | 0–≤ 5 | 1 |
| CTD | 0–≤ 5 | 1 |
| VT | 0–≤ 5 | 1 |
| VP | 0–≤ 5 | 1 |
| Bortezomib | 0–≤ 5 | 2 |
| > 5–≤ 10 | 1 | |
| > 10–≤ 25 | 7 | |
| > 25–≤ 50 | 0 | |
| VD | 0–≤ 5 | 2 |
| > 5–≤ 10 | 1 | |
| > 10–≤ 25 | 2 | |
| VTD | 0–≤ 5 | 2 |
| > 10–≤ 25 | 2 | |
| > 25–≤ 50 | 1 | |
| Bortezomib-based | > 5–≤ 10 | 1 |
| > 10–≤ 25 | 2 | |
| > 25–≤ 50 | 1 | |
| Dexamethasone | 0–≤ 5 | 5 |
| > 10–≤ 25 | 1 | |
| Lenalidomide maintenance | > 5–≤ 10 | 2 |
| > 10–≤ 25 | 2 | |
| > 25–≤ 50 | 1 | |
| RD | 0–≤ 5 | 1 |
| > 5–≤ 10 | 1 | |
| > 10–≤ 25 | 11 | |
| > 25–≤ 50 | 9 | |
| > 50–≤ 75 | 2 | |
| RP maintenance | > 5–≤ 10 | 1 |
| RVD | > 5–≤ 10 | 1 |
| > 10–≤ 25 | 1 | |
| Lenalidomide-based | > 10–≤ 25 | 2 |
| > 25–≤ 50 | 5 | |
| ERD | > 25–≤ 50 | 1 |
| MP | > 5–≤ 10 | 1 |
| > 25–≤ 50 | 2 | |
| MPT | > 10–≤ 25 | 1 |
| > 25–≤ 50 | 1 | |
| PAN-BTZ-Dex | > 25–≤ 50 | 1 |
| VCD | > 10–≤ 25 | 1 |
| > 25–≤ 50 | 2 | |
| VMP | > 10–≤ 25 | 1 |
| > 25–≤ 50 | 2 | |
| VMPT | > 25–≤ 50 | 1 |
| PAD | > 10–≤ 25 | 2 |
| RCD consolidation | > 10–≤ 25 | 1 |
| PD | > 25–≤ 50 | 4 |
| PVD | > 25–≤ 50 | 1 |
| IRD | > 10–≤ 25 | 1 |
| Vorinostat + bortezomib | > 10–≤ 25 | 1 |
| KRD | > 25–≤ 50 | 1 |
| MPR | > 50–≤ 75 | 1 |
| > 75–100 | 1 | |
| CHOP | > 50–≤ 75 | 1 |
| HD-M | > 50–≤ 75 | 1 |
| > 75–100 | 3 | |
| VTD-PACE | > 50–≤ 75 | 1 |
| > 75–100 | 1 | |
| PACE | > 75–100 | 1 |
CHOP cyclophosphamide/doxorubicin/vincristine/prednisone, CTD cyclophosphamide/thalidomide/dexamethasone, ERD elotuzumab/lenalidomide/dexamethasone, HD-M high-dose melphalan, IRD ixazomib/lenalidomide/dexamethasone, KRD carfilzomib/lenalidomide/dexamethasone, MP melphalan/prednisone, MPR melphalan/prednisone/lenalidomide, MPT melphalan/prednisone/thalidomide, PACE cisplatin/doxorubicin/cyclophosphamide/etoposide, PAD bortezomib/doxorubicin/dexamethasone, PD pomalidomide/dexamethasone, PVD pomalidomide/bortezomib/dexamethasone, PAN-BTZ-Dex panobinostat/bortezomib/dexamethasone, RCD lenalidomide/cyclophosphamide/dexamethasone, RD lenalidomide/dexamethasone, RCP lenalidomide/cyclophosphamide/prednisone, RP lenalidomide/prednisone, RVD lenalidomide/bortezomib/dexamethasone, VCD bortezomib/cyclophosphamide/dexamethasone, VD bortezomib/dexamethasone, VMP bortezomib/melphalan/prednisone, VMPT bortezomib/melphalan/prednisone/thalidomide, VP bortezomib/prednisone, VT bortezomib/thalidomide, VTD bortezomib/thalidomide/dexamethasone, VTD-PACE bortezomib/thalidomide/dexamethasone/cisplatin/doxorubicin/cyclophosphamide/etoposide