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. 2018 Feb 2;8:2265. doi: 10.1038/s41598-018-20527-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Generation of caspase-dependent large DNA fragments in response to other DNA damaging agents. (A) Effects of caspase inhibition on BPDE-treated cells. HeLa cells were pre-incubated with DMSO or Z-VAD-FMK (20 μM), treated with BPDE (1 μM) and harvested at the indicated time points. The cells were then analyzed for the generation of large DNA fragments and excised oligomers released from genomic DNA. Quantitative analysis of the generation of large DNAs (B) is also shown. (C) Effects of caspase inhibition on CPT-treated cells. HeLa cells were pre-incubated with DMSO or Z-VAD-FMK (20 μM), treated with CPT (20 μM) and analyzed as in (A). A longer exposure of the 20–40 nt region of the blot is provided to show that camptothecin does not induce canonical NER products. Quantitative analysis of the generation of large DNAs is shown in (D).