Figure 3.

Analysis of monopolar and bipolar cytokinesis selective phosphorylation. (a) Conservation scores of the monopolar selective, bipolar selective and shared phosphorylation sites are shown. Median scores of phosphorylation sites found in monopolar cytokinesis and in both are significantly different (Mann-Whitney U test). (b,c) The reconstructed interaction networks of monopolar selective (b) and bipolar selective (c) cytokinesis are shown where both phosphorylated proteins (green) and hidden proteins (called Steiner proteins, grey) are represented in a network context. Highly interconnected subnetworks are highlighted in red rectangles and enriched GO Cellular Component and Biological Process terms for each subnetwork are reported. The proteins are organized based on their sub-cellular compartments (plasma membrane, cytoplasm, cytoskeleton and nucleus). The ones with more than one annotated location are only illustrated in one compartment. (d) Number of sumoylation sites found within +/−14 amino acids of monopolar and bipolar specific phosphorylation sites. Phosphorylation sites are centered to 0 and the number of sumoylation sites residing upstream and downstream of the phosphorylation sites are reported.