Table 1.
Clinical characteristics of the first case/control study in Southern Chinese population.
| Characteristics | Control subjects (n = 616) | Stroke patients | |||
|---|---|---|---|---|---|
| Total cases (n = 543) | Hemorrhagic stroke (n = 94) | Atherothrombotic stroke (n = 224) | Lacunar infarction (n = 225) | ||
| Age, years | 63.6 ± 11.9 | 65.9 ± 12.2** | 63.5 ± 13.8 | 65.9 ± 11.6* | 70.0 ± 11.9** |
| Male, n (%) | 284 (46.1%) | 336 (56.3%)** | 54 (36.5%) | 121 (54.0%)* | 130 (57.8%)* |
| Body mass index, kg/m2 | 24.00 ± 2.28 | 23.90 ± 2.89 | 23.86 ± 2.91 | 24.18 ± 2.97 | 23.66 ± 2.77 |
| Systolic BP, mmHg | 136 ± 10 | 146 ± 23** | 164 ± 28** | 143 ± 19** | 143 ± 22** |
| Diastolic BP, mmHg | 83 ± 8.23 | 88 ± 14** | 99 ± 18** | 86 ± 11** | 86 ± 12** |
| Glucose, mmol/L | 5.41 ± 1.59 | 6.19 ± 2.52** | 6.82 ± 3.38** | 6.31 ± 2.17** | 5.81 ± 2.37* |
| Total cholesterol, mmol/L | 5.16 ± 0.98 | 4.64 ± 1.99** | 4.91 ± 1.36* | 4.68 ± 2.64** | 4.49 ± 1.35** |
| Triglycerides, mmol/L | 1.40 (0.95–1.77) | 1.31 (0.91–1.92) | 1.09 (0.82–1.80)* | 1.42 (1.0–2.13) | 1.31 (0.93–1.80) |
| Plasma uric acid, µmol/L | 280.79 ± 61.89 | 306.29 ± 103.76** | 336.07 ± 129.00** | 303.06 ± 100.01** | 296.79 ± 92.94* |
| Smoking, n (%) | 36 (5.8%) | 145 (26.7%)** | 30 (20.3%)** | 52 (23.2%)** | 63 (28.0%)** |
| Alcohol intake, n (%) | 47 (7.6%) | 120 (22.1%)** | 28 (18.9%)** | 48 (21.4%)** | 44 (19.6%)** |
| History of hypertension, n (%) | 313 (50.8%) | 324 (59.7%)* | 69 (46.6%)** | 138 (61.6%)* | 118 (52.4%) |
| History of diabetes, n (%) | 102 (16.6%) | 110 (20.3%) | 17 (11.5%) | 58 (25.9%)* | 36 (16.0%) |
| History of CHD, n (%) | 2 (0.3%) | 77 (14.2%)** | 13 (8.8%)** | 38 (17.0%)** | 26 (11.6%)** |
| Telomerase length (Ln-T/S ratio) | 1.75 ± 0.71 | 1.65 ± 0.95 | 1.62 ± 1.04 | 1.45 ± 0.95** | 1.87 ± 0.87* |
Abbreviations: BP, blood pressure; CHD, coronary heart disease. Telomere length is expressed as a relative telomere repeat copy/single-copy gene (T/S) ratio, and Ln(T/S) is natural logarithm transformed leucocyte telomere length T/S ratio. Values are mean ± SD, number (percentage), or median (interquartile range).
*P < 0.05, **P < 0.01, stroke patients vs. control subjects. The two-sample t-test was used for comparison of continuous variables, the chi-square test for categorical variables, and the Mann–Whitney U test for Triglycerides and relative T/S ratio.