Table 2.

Associations between leucocyte telomere length and stroke in the first case/control study of Southern Chinese population.

Variables	Highest tertile (>2.06)	Middle tertile (1.52–2.06)	Lowest tertile (<1.52)	P trend	Per 1-S.D. decrease in Ln-transformed telomere length	P
Controls (n = 616)	206	205	205
Total cases (n = 543)	179	147	217
ORs (95% CI)
No adjustment	1.0	0.83 (0.62–1.11)	1.22 (0.92–1.61)	0.03	1.11 (1.00–1.22)	0.048
Model I	1.0	0.79 (0.55–1.13)	1.04 (0.74–1.47)	0.23	1.07 (0.95–1.21)	0.27
Model II	1.0	0.82 (0.56–1.20)	1.05 (0.72–1.51)	0.38	1.07 (0.94–1.22)	0.33
Hemorrhagic stroke (n = 94)	33	21	40
ORs (95% CI)
No adjustment	1.0	0.64 (0.36–1.14)	1.22 (0.74–2.01)	0.08	1.16 (0.96–1.42)	0.13
Model I	1.0	0.82 (0.34–1.97)	0.91 (0.40–2.07)	0.91	1.08 (0.80–1.46)	0.61
Model II	1.0	0.73 (0.27–1.97)	0.89 (0.36–2.20)	0.82	1.05 (0.75–1.46)	0.78
Atherothrombotic stroke (n = 224)	51	67	106
ORs (95% CI)
No adjustment	1.0	1.32 (0.87–1.99)	2.09 (1.42–3.07)	0.001	1.39 (1.21–1.60)	<0.001
Model I	1.0	1.47 (0.90–2.40)	2.39 (1.50–3.80)	0.001	1.49 (1.26–1.75)	<0.001
Model II	1.0	1.43 (0.84–2.41)	2.33 (1.42–3.83)	0.003	1.48 (1.24–1.76)	<0.001
Lacunar infarction (n = 225)	95	59	71
ORs (95% CI)
No adjustment	1.0	0.62 (0.43–0.91)	0.75 (0.52–1.08)	0.04	0.87 (0.75–1.00)	0.053
Model I	1.0	0.50 (0.31–0.79)	0.51 (0.32–0.80)	0.003	0.74 (0.61–0.88)	0.001
Model II	1.0	0.52 (0.31–0.85)	0.49 (0.30–0.81)	0.007	0.72 (0.59–0.88)	0.001

The cut-off values of tertile of leucocyte telomere length (relative T/S ratio) were derived from the control group, with <1.52 for the lowest, 1.52–2.06 for the middle and >2.06 for the highest tertile (as the reference). OR (95% CI) was obtained with multivariate logistic regression analysis.

Model I: adjustment for age, gender, systolic and diastolic BP, fasting glucose, total cholesterol, triglycerides, plasma uric acid, and body mass index.

Model II: adjustment for the covariates mentioned above plus smoking status, alcohol intake, history of hypertension, diabetes, and previous CHD.