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. 2018 Feb 2;15:32. doi: 10.1186/s12974-018-1077-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — STF-083010, an IRE1α inhibitor, reduced brain infarction at 24 and 72 h post HI. a–c Representative photographs of TTC-stained coronal brain sections (a), quantitative analysis of infarct volume (b), and body weight gain (c) with single-dose treatment at 24 h post HI. d–f. Representative photographs of TTC-stained coronal brain sections (d), quantitative analysis of infarct volume (e), and body weight gain (f) with multi-dose treatment at 72 h post HI. Data are represented as mean ± SEM, n = 6 in each group. **P < 0.01 compared with sham group, ^##P < 0.01 compared with HI group, ^#P < 0.05 compared with HI group, ^§§P < 0.01 compared with vehicle+HI group, and ^&P < 0.05 compared with STF-15+HI group. STF: STF-083010, an IRE1α RNase-specific inhibitor. STF-15: STF-083010 (15 μg/pup). STF-45: STF-083010 (45 μg/pup)