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. 2018 Feb 2;30:9. doi: 10.1186/s40557-018-0219-y

Table 4.

Risks of leukemia (excluding CLL) in epidemiological studies of nuclear workers

Mean Number of event cases
Country Study Cohort size Exposure
period
Follow-up
period
cumulative
dose
(mSv)
Person
years
Types of events ERR
(95% CI)
SMR or SIR (95% CI)
15-country Cardis et al. (2007) [23] 407,391 1943-2000 1943-2000 19.4 5,192,710 Mortality 196 1.93
b(<0, 7.14)
-
3-country
(INWORKS)
Leuraud et al. (2015) [24] 308,297 1943-2005 1944-2005 15.9mGy 8,220,000 Mortality 531 2.96 (1.17, 5.21) -
Korea aAhn et al. (2008) [64] 79,679 1984-2004
1984-2004
1992-2004
1989-2005
6.1
6.1
633.159
415,298
Mortality
Morbidity
9
14
16.8
b(-34, 149) 15.8
b(-31, 108)
0.59 (0.28, 1.06)
Jeong et al. (2010) [65] 8,429 1978-2005 1992-2005 19.86 63,503 Incidence 3 NC 1.34 (0.27, 3.92)
U.K. Muirhead et al. (2009) [63] 174,541 1946-2001 1965-2001 24.9 3,900,000 Mortality
Incidence
198
234
1.71 (-0.17, 4.92) 1.78 (-0.06, 4.99) 0.89 (0.76, 1.03)
U.S. Howe et al. (2004) [66] 53,698 Mid-1960s 1979-1997 25.7 698,051 Mortality 26 5.67 (-2.56, 30.4) a
1.07 (0.71, 1.53)
Canada Zablotska et al. (2014) [67] 45,316 1951-1994 1956-1994 21.64 613,648 Mortality 17 9.79 (<-1.49, 107) 0.78 (0.45, 1.25)
France Flamant et al. (2013) [30] 59,021 1950-2004 1968-2004 16.1 1,467,611 Mortality 60 3.96
b(<0, 16.82)
-
Germany Merzenich et al. (2014) [68] 8,972 1966-2008 1991-2008 29.5 130,737 Mortality 7 - 1.19 (0.41, 2.75)
aJapan Akiba et al. (2012) [28] 200,583 1977-2002 1991-2002 12.2 1,373,000 Mortality 80 -1.93 (-6.12, 8.57) -
Russia Shilnikova et al. (2003) [25] 21,557 1948-1997 1948-1997 810 mGy 720,000 Mortality 66 1
b(0.5, 2)
-

a all leukemia; b 90% CI; NC was no convergence of deviance after maximum iteration. CLL, chronic lymphocytic leukemia