Table 6.
Risk of chronic lymphocytic leukemia in epidemiological studies of radiation exposure
| Cohort (patients or workers) | Study | Events | Cohort size |
Number of events | Risk |
|---|---|---|---|---|---|
| Ankylosing spondylitis | Weiss et al. (1995) [69] | Mortality | 15,577 | 7 | RR=1.44 (95% CI: 0.62, 2.79) |
| Benign locomotor lesions | Damber et al. (1995) [70] | Incidence | 20,024 | 50 | SIR=1.07 (95% CI: 0.80, 1.41) |
| Benign gynecological disease | Inskip et al. (1993) [71] | Mortality | 12,955 | 21 | RR=1.1 (90% CI: 0.5, 3.0) |
| Breast cancer | Curtis et al. (1989) [72] | Incidence | 22,753 | 10 | RR=1.84 (90% CI: 0.5, 6.7) |
| Uterine corpus cancer | Curtis et al. (1994) [73] | Incidence | 110,000 | 54 | RR=0.90 (95% CI: 0.4, 1.9) |
| International Radiation | Boice et al. (1988) [42] | OR=1.03 (90% CI: 0.3, 3.9) | |||
| Study of Cervical Cancer Patients | Incidence | 11,030 | 52 | ||
| Chernobyl liquidators | Romanenko et al. (2008) [74] | Incidence | 110,645 | 39 | ERR/Sv=4.09 (95% CI: <0, 14.41) |
| Chernobyl liquidators | Kesminiene et al. (2008) [20] | Incidence | 146,000 | 21 | ERR/Sv=4.7 (90% CI: -®, 76.1) |
| France nuclear workers | Flamant et al. (2013) [30] | Mortality | 59,021 | 18 | ERR/Sv=-1.36 (90% CI: <0, 14.94) |
| IARC 15-country nuclear workers |
Cardis et al. (2007) [23] | Mortality | 407,391 | 47 | ERR/Sv=-1.0 (90% CI: -5.0, 3.7) |
| U.K. NRRW | Muirhead et al. (2009) [63] |
Mortality | 174,541 | 69 | ERR/Sv=<-1.92 (90% CI: <-1.92, 1.23) |
| Incidence | 174,541 | 128 | ERR/Sv=-0.117 | ||
| (90% CI: -1.42, 2.71) | |||||
| INWORKS | Leuraud et al. (2015) [24] | Mortality | 308,297 | 138 | ERR/Gy=-1.06 (90% CI: <0, 1.81) |
RR, relative risk; OR, odds ratio; ERR, excess relative risk; CI, confidence interval; IARC, International Agency for Research on Cancer; NRRW, National Registry for Radiation Workers; INWORKS, International Nuclear Workers Study; ; SIR, standardized incidence ratio