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. 2018 Feb 2;13:7. doi: 10.1186/s13027-018-0179-4

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Number of aa mutations in the pre-S/S region. Number of aa mutations in the pre-S/S region (a), and mutations were also shown in pre-S1 and pre-S2 region (b). No significant difference in the average number of aa mutations was detected between HBsAg-positive and OBI-related HCC. The proportion of the major variant populations based on the pre-S2 region was significantly higher in OBI-related HCC than in HBsAg-positive HCC