Table 3.
The frequencies of specific amino acid mutations associated with the major and minor population of HBV quasispecies
| Region | Position | HBsAg positive (n = 10) | OBI (n = 9) | P value |
|---|---|---|---|---|
| Major population | ||||
| S | I126S/T | 30 | 0 | 0.040 |
| Y200F/S | 0 | 33.3 | 0.025 | |
| Y206C/H/S | 30 | 0 | 0.040 | |
| Minor population | ||||
| Pre-S | W4R | 0 | 33.3 | 0.025 |
| S5A/P/T | 30 | 0 | 0.040 | |
| L30S | 10 | 77.8 | 0.001 | |
| G35R | 30 | 0 | 0.040 | |
| H51P/R | 30 | 0 | 0.040 | |
| E54K | 50 | 0 | 0.006 | |
| A60V | 30 | 0 | 0.040 | |
| W77R/Stop | 30 | 0 | 0.040 | |
| I84T | 60 | 11.1 | 0.014 | |
| N98 K/T | 30 | 0 | 0.040 | |
| G102R | 30 | 0 | 0.040 | |
| Q118R/Stop | 0 | 44.4 | 0.008 | |
| N123D | 10 | 44.4 | 0.049 | |
| S124F/P | 0 | 33.3 | 0.025 | |
| S | L21F/S | 70 | 100 | 0.040 |
| L42F/S | 0 | 33.3 | 0.025 | |
| W182Stop | 30 | 0 | 0.040 | |
| L213F/I/T | 40 | 0 | 0.017 | |
Bold indicated the amino acid position which mutational frequencies in OBI were higher than those in HBsAg positive