Fig. 5.

Effect of SP-A variants on airway functions after Kp infection and in response to methacholine challenge (50 mg/mL) in males. The Rrs, Crs, Ers, Rn, G, and H (panel a, b, c, d, e, and f), were measured in male SP-A1 (6A², 6A⁴), SP-A2 (1A⁰, 1A³), SP-A1/SP-A2 (6A2/1A⁰, co-ex), and SP-A (KO) mice after a 50 mg/mL of methacholine challenge (bar graph). Inset: depicts the effect of dose response with increasing concentration of methacholine. Data are expressed as mean ± SD (4 replicates per group). *p < 0.05