Table 3.
Effect of cisplatin (CP) and different treatments of AHE on lung tissue protein, oxidative stress markers and lipid peroxidation
| Group | Protein (μg/mg Tissue) | H2O2 (nM/min/mg Tissue) | Nitrite (content μM/ml) | MDA (nM/min/mg protein) |
|---|---|---|---|---|
| Control | 1.722 ± 0.042b | 2.192 ± 0.025b | 44.59 ± 0.609b | 3.66 ± 0.265b |
| CP | 0.965 ± 0.072a | 5.752 ± 0.081a | 82.16 ± 1.531a | 8.649 ± 0.403a |
| AHE lone | 1.711 ± 0.056b | 2.148 ± 0.034b | 44.26 ± 0.385b | 3.599 ± 0.245b |
| CP + AHE | 1.237 ± 0.025a,b*,d** | 4.498 ± 0.073a,b,d | 68.14 ± 0.81a,b,d | 6.965 ± 0.214a,b**,d |
| AHE + CP | 1.582 ± 0.040b,c** | 3.049 ± 0.136a,b,c | 50.53 ± 0.410a**,b,c | 4.614 ± 0.184b,c |
| CP + Sily | 1.591 ± 0.075b | 2.99 ± 0.012a,b | 50.03 ± 1.149a*,b | 4.396 ± 0.208b |
Values expressed as mean ± SEM. a: Significance at p < 0.0001 Vs. control group, b: Significance at p < 0.0001 Vs. Cisplatin (CP) group. c: Significance at p < 0.0001 of AHE + CP pre-treated group Vs. CP + AHE post-treated group. d: Significance at p < 0.0001 of CP + AHE treatment groups Vs CP + Sily group. *, **: Significant difference at p < 0.05 and p < 0.001 respectively. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters (One way ANOVA followed by Tukey’s multiple comparison tests)