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. 2018 Feb 3;18:129. doi: 10.1186/s12885-018-4013-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Examples of TIL density grades. a) a case representing TIL density grade 0 (TILs are estimated to occupy 2% of the stromal area). H&E, original magnification 4×, scale bar 250 μm; b) a case representing TIL density grade 1 (TILs are estimated to occupy 20% of the stromal area). H&E, original magnification 5×, scale bar 200 μm; c) a case representing TIL density grade 2 (TILs are estimated to occupy 40% of the stromal area). H&E, original magnification 5×, scale bar 200 μm; d) a case representing TIL density grade 3 (TILs are estimated to occupy 60% of the stromal area). H&E, original magnification 5×, scale bar 200 μm. The circles show the areas sampled for tissue microarray construction