Table 3.
Pathobiological and TIL characteristics of pure DCIS (DCIS) and microinvasive carcinomas (miCa)
| DCIS (n = 96) |
miCa (n = 35) |
p value | |
|---|---|---|---|
| Characteristic | |||
| Lesion size (mm) | 12 ± 16 | 14 ± 20 | NS |
| Lesions ≥20 mm | 21 (21.9%) | 10 (28.6%) | NS |
| Architectural pattern | |||
| comedo | 26 (27.1) | 14 (40.0%) | NS |
| solid | 30 (31.3%) | 16 (45.7%) | NS |
| cribriform | 50 (52.1%) | 15 (42.9%) | NS |
| micropapillary | 31 (32.3%) | 7 (20.0%) | NS |
| Presence of necrosis | 61 (65.6%) | 27 (77.1%) | NS |
| Presence of microcalcifications | 71 (75.5%) | 27 (77.1%) | NS |
| Nuclear grade | |||
| low | 14 (14.6%) | 2 (6.3%) | NS |
| intermediate | 45 (46.9%) | 12 (34.3%) | NS |
| high | 37 (38.5%) | 21 (60.0%) | 0.029 |
| Mitotic index | 3.7 ± 4.0 | 4.8 ± 4.4 | NS |
| Ki67 index | 4.8 ± 7.3 | 5.6 ± 6.4 | NS |
| Molecular subtype | |||
| luminal | 67 (68.9%) | 15 (42.9%) | |
| HER2 | 17 (17.7%) | 11 (31.4%) | 0.032* |
| triple negative | 12 (12.5%) | 9 (25.7%) | |
| TIL density (TIL-d) | |||
| grade 0 | 15 (15.6%) | 1 (2.9%) | NS (0.07) |
| grade 1 | 43 (44.8%) | 16 (45.7%) | NS |
| grade 2 | 28 (29.2%) | 9 (25.7%) | NS |
| grade 3 | 10 (10.4%) | 9 (25.7%) | 0.028 |
| TIL phenotype | |||
| cells CD8+ | 65 ± 91 | 150 ± 224 | 0.016 |
| cells CD4+ | 106 ± 185 | 242 ± 320 | 0.001 |
| cells FoxP3+ | 22 ± 40 | 44 ± 92 | NS (0.08) |
| cells CD20+ | 134 ± 290 | 276 ± 504 | NS |
| cells CD38+ | 28 ± 39 | 57 ± 73 | 0.024 |
| T/B ratio | 7.2 [5.3–9.2] | 11.0 [5.2–16.8] | NS |
| CD8+/FoxP3+ ratio | 9.4 [5.1–13.7] | 11.1 [5.2–15.9] | NS |
Legend: Values given for individual lymphocyte subpopulations are mean ± SD; values for the ratios of lymphocyte counts are means and 95% CI Abbreviations: ER oestrogen receptor, PR progesterone receptor, NS not significant * = p value for the difference in global distribution of molecular subtypes between DCIS and miCa