Table 4.
Pathobiological and TIL characteristics of lymphocyte-poor (non-lyDCIS) and lymphocyte-rich non-invasive DCIS (lyDCIS)
| non-lyDCIS (n = 58) |
lyDCIS (n = 38) |
p value | |
|---|---|---|---|
| Characteristic | |||
| Lesion size (mm) | 11 ± 14 | 13 ± 19 | NS |
| Lesions ≥20 mm | 11 (18.6%) | 11 (28.9%) | NS |
| Architectural pattern | |||
| comedo | 9 (15.5%) | 17 (44.7%) | 0.0016 |
| solid | 18 (31.0%) | 12 (31.6%) | NS |
| cribriform | 29 (50.0%) | 21 (55.3%) | NS |
| micropapillary | 23 (39.7%) | 8 (21.1%) | NS |
| Presence of necrosis | 32 (55.2%) | 29 (82.9%) | 0.0065 |
| Presence of microcalcifications | 44 (75.9%) | 27 (75.0%) | NS |
| Nuclear grade | |||
| low | 14 (24.1%) | 0 (0%) | 0.001 |
| intermediate | 29 (50.0%) | 16 (42.1%) | NS |
| high | 15 (25.9%) | 22 (57.9%) | 0.0016 |
| Mitotic index | 2.4 ± 2.7 | 5.8 ± 4.7 | < 0.001 |
| Ki67 index | 3.4 ± 4.4 | 6.9 ± 9.9 | NS |
| Molecular subtype | |||
| luminal | 45 (77.6%) | 22 (57.9%) | |
| HER2 | 4 (6.9%) | 13 (34.2%) | 0.0059* |
| triple negative | 9 (15.5%) | 3 (7.9%) | |
| TIL density (TIL-d) | |||
| grade 0 | 15 | 0 | NA |
| grade 1 | 43 | 0 | NA |
| grade 2 | 0 | 28 | NA |
| grade 3 | 0 | 10 | NA |
| TIL phenotype | |||
| cells CD8+ | 42 ± 64 | 102 ± 113 | 0.0002 |
| cells CD4+ | 68 ± 138 | 165 ± 229 | 0.0018 |
| cells FoxP3+ | 7 ± 15 | 47 ± 54 | < 0.0001 |
| cells CD20+ | 57 ± 123 | 253 ± 411 | 0.00013 |
| cells CD38+ | 19 ± 33 | 41 ± 43 | 0.00051 |
| T/B ratio | 9.0 [6.2–11.7] | 4.6 [2.4–11.7] | 0.029 |
| CD8+/FoxP3+ ratio | 8.2 [5.1–11.3] | 11.6 [0.8–22.4] | NS |
Legend: Values given for individual lymphocyte subpopulations are mean ± SD; values for the ratios of lymphocyte counts are means and 95% CI. Abbreviations: NA not applicable, NS not significant, * = p value for the difference in global distribution of molecular subtypes between non-lyDCIS and lyDCIS