Table 2.
List of 31 CpG sites showing significant differences in methylation between centenarians and healthy controls
| Probe ID | P Value | FDR | Δ β | Gene | Region | Chromosome |
|---|---|---|---|---|---|---|
| Hypermethylated genes | ||||||
| cg24724428 | 9.49E-08 | 2.94E-03 | 0.203271068 | ELOVL2 | TSS1500 | 6 |
| cg23448505 | 1.09E-04 | 6.99E-02 | 0.210419612 | HKR1 | 5’UTR | 19 |
| cg14166009 | 1.10E-04 | 7.04E-02 | 0.206571283 | HKR1 | TSS1500 | 19 |
| cg13687570 | 1.46E-04 | 7.97E-02 | 0.224156561 | HKR1 | TSS1500 | 19 |
| cg26734888 | 2.82E-04 | 1.08E-01 | 0.215848099 | HKR1 | TSS1500 | 19 |
| cg12948621 | 2.86E-04 | 1.09E-01 | 0.201660605 | HKR1 | TSS200 | 19 |
| cg24834889 | 9.41E-04 | 1.79E-01 | 0.229230299 | HKR1 | TSS200 | 19 |
| cg05280698 | 1.95E-03 | 2.32E-01 | 0.22951704 | HKR1 | TSS200 | 19 |
| cg11949518 | 2.54E-03 | 2.52E-01 | 0.227662305 | RPTOR | Body | 17 |
| Hypomethylated genes | ||||||
| cg07839457 | 7.52E-08 | 2.94E-03 | −0.283566443 | NLRC5 | TSS1500 | 16 |
| cg04233669 | 2.70E-07 | 4.49E-03 | −0.210848478 | LOC153328 | Body | 5 |
| cg00008629 | 4.19E-07 | 5.21E-03 | −0.237495141 | ROD1 | 5’UTR | 9 |
| cg24892069 | 2.60E-05 | 2.07E-01 | −0.205487552 | NRP1 | TSS1500 | 10 |
| cg01499623 | 4.50E-05 | 4.55E-02 | −0.232050941 | SMU1 | Body | 9 |
| cg22359828 | 5.49E-05 | 5.01E-02 | −0.206320371 | CACNA1E | Body | 1 |
| cg03930097 | 7.66E-05 | 5.82E-02 | −0.201870989 | HLA-DRA | Body | 6 |
| cg04329478 | 9.57E-05 | 6.52E-02 | −0.259320244 | LOC400696 | TSS200 | 19 |
| cg17608381 | 1.24E-04 | 7.37E-02 | −0.331606794 | HLA-A | Body | 6 |
| cg04357717 | 3.55E-04 | 1.21E-01 | −0.210909327 | ZPLD1 | Body | 3 |
| cg11946459 | 3.56E-04 | 1.21E-01 | −0.283888936 | HLA-A | Body | 6 |
| cg13877915 | 8.02E-04 | 1.68E-01 | −0.241392036 | ZNF132 | TSS200 | 19 |
| cg26856631 | 9.82E-04 | 1.81E-01 | −0.409805022 | LSM5 | 3’UTR | 7 |
| cg25817503 | 1.20E-03 | 1.95E-01 | −0.227151237 | AFAP1 | Body | 4 |
| cg08309069 | 1.43E-03 | 2.07E-01 | −0.249630086 | HLA-C | TSS1500 | 6 |
| cg08124030 | 2.23E-03 | 2.41E-01 | −0.321896757 | TM4SF1 | 1stExon | 3 |
| cg05761882 | 2.59E-03 | 2.53E-01 | −0.213920774 | CAPN2 | Body | 1 |
| cg15295200 | 5.13E-03 | 3.14E-01 | −0.381483294 | NMNAT3 | TSS1500 | 3 |
| cg25637655 | 5.97E-03 | 3.28E-01 | −0.217322003 | HLA-A | Body | 6 |
| cg03263197 | 6.62E-03 | 3.36E-01 | −0.203535875 | UBL4B | TSS1500 | 1 |
| cg02746108 | 6.97E-03 | 3.40E-01 | −0.225251292 | AGAP1 | Body | 2 |
| cg05194426 | 8.66E-03 | 3.59E-01 | −0.230652944 | CYP2E1 | Body | 10 |