Table 4.
The AUC, 95% confidence intervals (95% CI), and sensitivity and specificity for ROC curves calculated at the optimal cutoff, together with the p-values for 16 significant lipidomic metabolites
| No. | Significant Metabolites | AUC | 95% CI | Sensitivity | Specificity | Cutoff value | p value |
|---|---|---|---|---|---|---|---|
| 1 | lysoPC 16:0 | 0.9 | 0.782–0.986 | 0.9 | 0.8 | 1.22 e + 07 | 0.000 |
| 2 | lysoPC 20:0 | 0.895 | 0.731–0.986 | 0.9 | 0.9 | 4.35 e + 07 | 0.000 |
| 3 | Acylcarnitine 21:4 | 0.888 | 0.746–0.978 | 0.8 | 0.8 | 1.35 e + 08 | 0.000 |
| 4 | Cer_NS 34:1 | 0.88 | 0.721–0.965 | 0.8 | 0.8 | 1.97 e + 06 | 0.000 |
| 5 | lysoPE 24:0 | 0.86 | 0.695–0.96 | 0.8 | 0.8 | 7.13 e + 06 | 0.000 |
| 6 | lysoPC 14:0 | 0.86 | 0.718–0.949 | 0.9 | 0.7 | 3.56 e + 08 | 0.000 |
| 7 | Acylcarnitine 26:0 | 0.85 | 0.71–0.954 | 0.8 | 0.9 | 3.84 e + 07 | 0.000 |
| 8 | lysoPC 24:0 | 0.85 | 0.685–0.976 | 0.8 | 0.9 | 7.27 e + 06 | 0.000 |
| 9 | lysoPE 18:2 | 0.845 | 0.69–0.958 | 0.9 | 0.8 | 1.18e + 08 | 0.000 |
| 10 | lysoPE 18:1 | 0.835 | 0.691–0.945 | 0.8 | 0.7 | 4.48 e + 07 | 0.000 |
| 11 | lysoPC 22:0 | 0.83 | 0.686–0.95 | 0.8 | 0.8 | 1.35 e + 07 | 0.000 |
| 12 | lysoPC 15:0 | 0.828 | 0.655–0.949 | 0.8 | 0.8 | 3.27 e + 06 | 0.000 |
| 13 | Cer_NS 36:2 | 0.82 | 0.672–0.941 | 0.8 | 0.8 | 6.36 e + 06 | 0.000 |
| 14 | Acylcarnitine 15: 3 | 0.82 | 0.674–0.951 | 0.8 | 0.8 | 7.42 e + 06 | 0.005 |
| 15 | Acylcarnitine 20: 0 | 0.805 | 0.635–0.942 | 0.8 | 0.8 | 6.39 e + 06 | 0.000 |
| 16 | lysoPC 22:5 | 0.802 | 0.638–0.929 | 0.8 | 0.8 | 1.5 e + 08 | 0.001 |