Fig. 2.

Model proposing the potential MHC II presentation of self-peptides after phagocytosis of infected apoptotic cells. During infection that causes apoptosis of host cells, APCs recognize “eat me” signals such as phosphatidylserine (PS) and engage receptors such as Stabilin-2, BAI-1 and TIM-4 along with TLRs [156]. Following phagocytosis of infected apoptotic cells, apoptotic cell (self) and microbial (non-self) peptides contained simultaneously within TLR ligand carrying phagosomes, can become presented by the APC, leading to stimulation of both pathogen-specific and self-reactive CD4⁺ T cells