(A) Schematic representation of the mechanotransducing role of fibrillin-1 assemblies in the myocardium as inferred from DMC characterization in Fbn1mgR/mgR mice. In this model, fibrillin-1 assemblies influence cross talk between AT1r and integrin by participating in ECM loading on the mechanosensors (B) Proposed role of fibrillin-1 in stem cell fate regulation by modulating TGFβ bioavailability within the bone marrow niche, as implied from the characterization of progressive bone loss in Fbn1Prx−/− mice. Arrows points to cellular processes of self-renewal, commitment and differentiation, while abbreviations signify mesenchyme stem cell (MSC), progenitor cell (PrC), osteoblast (Ob) and adipocyte (Ad).