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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Clin Pharmacokinet. 2018 May;57(5):577–589. doi: 10.1007/s40262-017-0576-7

Figure 1.

Figure 1

Ontogeny of AAG among healthy subjects. Concentrations, normalized to CRM470 values, are depicted using estimated geometric mean values (o) for each study group. Geometric error bars depict the log-normal SE associated with each study cohort. Predicted AAG concentrations based on a sigmoid Emax model (solid line - red), as derived from this work, and a linear model (dashed line - blue), as proposed by McNamara and Alcorn (assuming adult plasma AAG concentrations ≈ 93.17 mg/dL) [2], are denoted. Observed data were compiled from the following publications: [13, 18, 20, 21, 23, 29–49].