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Predictive performance of McNamara and Alcorn’s (linear) equation vs. the sigmoid Emax equation derived from this analysis at estimating observed pediatric fraction unbound (fup; n=17) values. Solid and dashed lines depict the lines of best fit (i.e. linear regression) for estimates derived from the sigmoid Emax and linear equations, respectively. The line of identity (dotted) is superimposed for reference.
