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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Clin Pharmacokinet. 2018 May;57(5):577–589. doi: 10.1007/s40262-017-0576-7

Table 1.

Ontogeny models investigated

Model Equation1
Linear2 (a * AGE) + b
Power2 b *AGEa
Exponential2 b * ea * AGE
Linear-Log2 b + [a *ln(AGE)]
Sigmoid Emax3
AAGmaxAGEPTM50P+AGEP
1

the covariate AGE was specified using either postnatal age (days) or postmenstrual age (weeks)

2

a and b denote estimable parameters associated with the linear, power, exponential, and linear-log models

3

AAGmax (maximum plasma AAG concentration [mg/dL]), TM50(age at 50% AAGmax [days or weeks]), and P (Hill coefficient) denote estimable parameters associated with the sigmoid Emax model