Fig. 1.
Chemical structure and activity of clioquinol. A, chemical structure of clioquinol. B–I, comparison of the effects of ZnCl2 and clioquinol on A. baumannii (B–E) and E. coli (F–I) resistance to amikacin. A. baumannii A155 or E. coli TOP10(pNW1) cells were cultured in 100 μl Mueller-Hinton broth in microtiter plates at 37°C with the indicated additions. Panels show the effect of addition of different concentrations of amikacin (B, F), clioquinol (C, G), ZnCl2 (D, H), or combinations of two or the three reagents (E, I). Boxed concentrations are those used in panels E and I.