Figure 7.

EHDV-TAU infection dramatically changing the proteome of IL-6-treated LNCaP-JAK1 cells. (A) Heatmap of differently expressed proteins (|log₂ ratio| of average (n = 4) ≥ 0.5) in LNCaP or LNCaP-JAK1 cells under different conditions. Labeled cells were treated with IFNα (200 U/mL) or IL-6 (5 ng/mL) for 16 h, followed by EHDV-TAU infection (moi = 0.5, 24 h, in the presence of IL-6 or IFNα) where indicated. Sorting of the 363 differently expressed proteins––high (red) to low (green)––was according to the most extensively altered condition (EHDV-TAU + IL-6). (B) Heatmap of 50 differently expressed ISGs in each of the indicated conditions [generated by crossing the list of 363 differently expressed proteins with a list of 500 known ISGs (15, 63), sorted as in (A)]. Average (n = 4) |log₂ ratio| fold change in expression is presented.