Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 30;12:20. doi: 10.3389/fncel.2018.00020

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Bohannon and Hablitz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

HCN channel inhibition exerts cell-type specific effects on intrinsic excitability. Scatter plots showing (A) the resting membrane potential (RMP), (B) input resistance (R_IN), (C) initial firing frequency, (D) action potential (AP) half-width and (E) AP rise time of cells in each group before (black circles) and after (red squares) wash-on of the HCN channel antagonist ZD7288. Group 1 showed the largest effects whereas Group 2 cells displayed no modulation of intrinsic excitability by HCN channels. *p < 0.05, paired t-test. Each shape represents an individual cell. Error bars are mean ± SEM.