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. 2018 Jan 30;12:20. doi: 10.3389/fncel.2018.00020

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Copyright © 2018 Bohannon and Hablitz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Developmental modulation of synaptic integration by HCN channels. (A) Graphs quantifying the effects of HCN channel blockade (red squares) on EPSP summation (left) and the total AUC of evoked EPSPs (right) in RS Group 1 cells recorded at p10–12. (B–D) Same as in (A), but for cells recorded at p13–15 (B), p16–18 (C), and p19–21 (D), showing that in RS cells, modulation by HCN channels increases developmentally. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, 2-way ANOVA. *p < 0.05, Dunn-Sidak’s post-test. Error bars are mean ± SEM.